In the match before the November international window, the Lionesses return to Princes Park for the second straight weekend to take on a gritty Birmingham City side.
The second scoreless draw of the season for London City sees itself third in the table, with a game in hand over the second-place Southampton on 17 points, and just five points behind the unbeaten leaders, Bristol City.
In the previous match week, the Blues came from behind at home to snatch all three points away from Sheffield United.
Birmingham mustered up two goals in the last 20 minutes of the match, including a potential goal-of-the-season candidate from Irish international Lucy Quinn.
Her strike from outside the box right at the end of stoppage time sealed the Blues' triumph.
The Blues have won three out of their last four contests in all competitions, including a 3-2 victory over WSL side, Brighton and Hove Albion in the Conti Cup.
Birmingham City is one of two teams that have played in just six contests so far.
The combination of Quinn and Louise Quinn along with Liverpool loanee Ashley Hodson have netted six out of the last eight goals for the Blues.
Although London City did not find the back of the net against Blackburn, no team has scored on the Lionesses in the Championship since Charlton scored three at the end of August.
London City is tied for the league lead in goals scored with 14, including five from Scottish striker Sarah Ewens to go along with three from Amy Rodgers in the midfield.
These two teams have met just once before back in the Conti Cup group stage in December of 2021 at Princes Park.
The Lionesses fought the Blues to a 2-2 draw with London City emerging victorious in the penalty shootout, 5-4.
With an uplifting result under its belt from last week, Birmingham City heads back on the road to disrupt the form that the Lionesses have been on since the opening day of the season.
Head Coach, Melissa Phillips
"We are all excited about the opportunity at the weekend. We know it will be a high-level game as both oppositions have quality in abundance within our squads.
"Birmingham are coming off the back of an emotional performance with a late winner so we know the momentum that it brings. We will have to remain dominant out of possession and bring a grittiness to the match.
"This week has been about enjoyment with the ball and we are looking forward to being at home again and really asserting ourselves in possession."